Shift work sleep disorder (SWSD) is associated with numerous negative consequences including drowsy driving accidents, dangerous workplace mistakes, and reduced quality of life. Fortunately, the wakefulness-promoting medication modafinil is effective in treating SWSD.
On the DEQ, both doses of Buy Modafinil Online attenuated shift change-related impairments, as demonstrated in the upper panels of Figure 2. Subjective-effect ratings also improved with the drug (Table 1).
Reduces Extreme Sleepiness
Those suffering from shift work sleep disorder struggle with extreme fatigue and difficulty staying awake during their night shift. This condition impacts their quality of life, and they are prone to mistakes, accidents, and mishaps that can lead to serious personal and professional consequences. A medication originally developed for narcolepsy called Modafinil is a promising treatment for SWSD. It improves sleep latency, reduces attention lapses, and enhances cognitive functions.
This drug is a central nervous system stimulant, and it affects noradrenergic (specifically the dopamine transporter), GABAergic, glutaminergic, and histaminergic systems to promote wakefulness. It also acts on melatonin receptors to decrease sleepiness.
The drug is a good choice for patients struggling to fall asleep, as it can help them stay alert and active during their night shift. Those taking this medication should follow good sleep habits, including sleeping in a dark and quiet room and avoiding caffeine close to bedtime. They should also be careful not to take too much as this can lead to withdrawal symptoms such as shaking, sweating, chills, and confusion.
Enhances Mental Performance
Many people struggle with the need to work hard. While there are plenty of stories of entrepreneurs and millennials with unwavering focus and powering through 14-hour days, it’s important to find a balance.
A 12-week, randomized, placebo-controlled trial was conducted to evaluate the efficacy of modafinil (200 mg or 400 mg) and placebo on patient functioning and health-related quality of life in shift workers with SWSD.
Patients were administered modafinil or placebo 30 to 60 minutes before each night shift.
The results showed that both active doses of modafinil significantly improved cognitive/psychomotor performance compared with placebo. Modafinil increased the tracking speed on the DAT and the number of correct responses on the DSST, and it reduced total misses and false alarms on the RIT task. Modafinil also improved mood compared with placebo.
However, the study was only 12 weeks long, and tolerance to the drug might have developed by the end of the experiment. Therefore, further studies of longer duration are needed to assess the clinical usefulness of this wake-promoting medication.
Increases Energy Levels
Modafinil is an effective wake-promoting medication that increases energy levels in patients with shift work sleep disorder. It has also been shown to decrease performance disruptions due to night shift work.
The drug is a stimulant that is similar to amphetamine, but has lower abuse potential and does not have the same pharmacological properties. It is thought to increase monoamine release in the brain. It is used to treat narcolepsy, but it may also improve the symptoms of shift work sleep disorders (SWSD).
SWSD can have serious personal and professional consequences for those who suffer from it. It can lead to fatigue, lapses in attention, and impaired cognitive functions. It can also impact your daily routine and sleep patterns. Treatment options include making changes to your schedule and routine at home, as well as the use of wake-promoting medications. One such medication is Modafinil, which was originally developed for narcolepsy. It has been shown to significantly reduce sleepiness in narcolepsy and to improve SWSD.
Reduces Fatigue
Modafinil significantly reduces fatigue in people with shift work sleep disorders and narcolepsy. However, it is important to remember that it is a drug that needs to be taken regularly and cannot be used as a substitute for getting enough rest.
In a double-blind within-participant study of participants with chronic shift work sleep disorder (SWSD), modafinil significantly improved cognitive performance, mood ratings, and objective measures of daytime functioning relative to placebo during a 3-day simulated shift change. However, modafinil did not improve sleep onset latency on the night shift.
The upper panels of Figure 2 show selected subjective effect ratings during the shift change in each treatment condition. Ratings for ‘Alert’ were decreased on two nights when participants were assigned to the placebo condition compared with the corresponding night-shift conditions, while ratings for ‘Sleepy’ and ’Can’t Concentrate’ were increased on those nights. Modafinil reversed these effects on shift-change day and evening. A larger dose also attenuated shift-change-associated changes in sleep onset latency.